What color cat is always male or Female?
Most Orange cats are male and most Calicos are female. The color of a cat's coat is closely linked to its gender. As you may recall from high school biology, mammals have two chromosomes that determine their sex—XX for females and XY for males.
Calico cats are predominantly female because they're coloring is related to the X chromosome. I'll try not to put you to sleep with a complicated genetics lesson, so here's a quick overview: Two X chromosomes are needed for a cat to have that distinctive tri-color coat. If a cat has an XX pair, she will be female.
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